Article
Lymphoma induction by human B cells in scid mice.
Leukemia - 1 Jan 1992
Amadori A, Veronese M L, Mazza M R, Zamarchi R, Mion M, D'Andrea E, Menin C, Del Mistro A, Leszl A, Calderazzo F
Abstract excerpt
Lymphoma development was studied in scid mice injected i.p. with PBMC from EBV-positive donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the injected cell populations preve...
Topics
- Animals
- B-Lymphocytes
- Herpesvirus 4, Human
- Humans
- Immunocompromised Host
- Lymphoma, B-Cell
- Mice
- Mice, SCID
- Phenotype