Heterogeneity among Epstein-Barr virus-seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts.

Abstract excerpt

Epstein-Barr virus (EBV) is associated with B-cell malignancy in immunosuppressed humans and SCID mice receiving human peripheral blood leukocyte grafts (hu-PBL-SCID). We have further characterized the process of lymphoma development in hu-PBL-SCID mice. We report that EBV-seropositive donors differ markedly in the capacity of their PBL to give rise to immunoblastic lymphomas in SCID mice; some donors (high...

Topics

• Age Factors
• Animals
• DNA Replication
• Herpesvirus 4, Human
• Humans
• Incidence
• Leukocyte Transfusion
• Leukocytes
• Lymphoma, B-Cell
• Mice
• Mice, SCID