Article
Epstein-Barr virus-induced human B-cell lymphoma arising in HuPBL-SCID chimeric mice: characterization and the role of CD40 stimulation in their treatment and prevention.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1995
Funakoshi S, Beckwith M, Fanslow W, Longo D L, Murphy W J
Abstract excerpt
The transfer of human peripheral blood lymphocytes (huPBL) from EBV-seropositive donors into mice with severe combined immune deficiency (SCID) has been shown previously to result in the generation of human EBV-induced B-cell lymphomas. These lymphomas are similar to the aggressive lymphomas that arise clinically in immunocompromised individuals. We have assessed the p53 status of these human B-lymphomas and the...
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