Article
Epstein-Barr virus-induced human B-cell lymphoma arising in HuPBL-SCID chimeric mice: characterization and the role of CD40 stimulation in their treatment and prevention.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1995
Funakoshi S, Beckwith M, Fanslow W, Longo D L, Murphy W J
Abstract excerpt
The transfer of human peripheral blood lymphocytes (huPBL) from EBV-seropositive donors into mice with severe combined immune deficiency (SCID) has been shown previously to result in the generation of human EBV-induced B-cell lymphomas. These lymphomas are similar to the aggressive lymphomas that...
Topics
- Animals
- Antibodies, Monoclonal
- CD40 Antigens
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Clone Cells
- Herpesvirus 4, Human
- Humans
- Lymphoma, B-Cell
- Mice
- Mice, SCID
- Mutation
- Transplantation Chimera
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53