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Article

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

The Journal of experimental medicine - 1 Jan 1991

Rowe M, Young L S, Crocker J, Stokes H, Henderson S, Rickinson A B

Abstract excerpt

When human peripheral blood lymphocytes (PBLs) from Epstein-Barr virus (EBV)-seropositive donors are injected intraperitoneally into SCID mice, EBV+ B cell tumors develop within weeks. A preliminary report (Mosier, D. E., R. J. Gulizia, S. M. Baird, D. D. Richman, D. B. Wilson, R. I. Fox, and T. J. Kipps, 1989. Blood. 74(Suppl. 1):52a) has suggested that such tumors resemble the EBV-positive malignancy, Burkitt's...

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Identifiers

PMID: 1845872
DOI: 10.1084/jem.173.1.147
PMCID: PMC2118756

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