Article
Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.
The Journal of experimental medicine - 1 Jan 1991
Rowe M, Young L S, Crocker J, Stokes H, Henderson S, Rickinson A B
Abstract excerpt
When human peripheral blood lymphocytes (PBLs) from Epstein-Barr virus (EBV)-seropositive donors are injected intraperitoneally into SCID mice, EBV+ B cell tumors develop within weeks. A preliminary report (Mosier, D. E., R. J. Gulizia, S. M. Baird, D. D. Richman, D. B. Wilson, R. I. Fox, and T....
Topics
- Animals
- Antigens, Surface
- Antigens, Viral
- Cell Line
- Chimera
- Gene Expression
- Herpesvirus 4, Human
- Humans
- Immunologic Deficiency Syndromes
- Lymphoma
- Lymphoproliferative Disorders
- Mice
- Phenotype
- Tumor Virus Infections