Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

doi:10.1073/pnas.90.9.3988

Article

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1 May 1993

Abstract excerpt

Infection with certain types of human papillomaviruses (HPV) is highly associated with carcinomas of the human uterine cervix. However, HPV infection alone does not appear to be sufficient for the process of malignant transformation, suggesting the requirement of additional cellular events. After DNA damage, normal mammalian cells exhibit G1 cell-cycle arrest and inhibition of replicative DNA synthesis. This...

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