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Article

Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins.

International journal of cancer - 15 Mar 2001

Park J S, Kim E J, Lee J Y, Sin H S, Namkoong S E, Um S J

Abstract excerpt

Human papillomavirus (HPV) is strongly implicated as a causative agent in the etiology of cervical cancer. Of its gene products, E6 binds to and inactivates p53 tumor suppressor protein by ubiquitin/proteasome-dependent degradation. Recently, p73, a novel family of p53, has been identified and demonstrated, like p53, to activate p21(WAF1). Here we show that p73 is also inactivated by HPV-E6, but...

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Identifiers

PMID: 11275986
DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1130>3.0.co;2-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins.PMID 11275986Read ↗

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