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Article

The effects of gonadectomy on glucose tolerance of genetically obese (fa/fa) rats: influence of sex and genetic background.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Feb 1992

Kava R A, West D B, Lukasik V A, Wypijewski C, Wojnar Z, Johnson P R, Greenwood M R

Abstract excerpt

In both humans and rodents the occurrence and severity of obesity-associated non-insulin dependent diabetes mellitus (NIDDM) may be influenced by both gonadal hormones and genetic background. Early gonadectomy (at 3-5 days of age) of female and male Wistar diabetic fatty (WDF) rats and of male Zucker rats allowed us to examine these effects in genetically obese rats carrying the fatty (fa) gene. Impairment of...

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PMID: 1316324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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