A new obesity-prone, glucose-intolerant rat strain (F.DIO).

doi:10.1152/ajpregu.00267.2003

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Article

A new obesity-prone, glucose-intolerant rat strain (F.DIO).

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Nov 2003

Levin Barry E, Dunn-Meynell Ambrose A, McMinn Julie E, Alperovich Michael, Cunningham-Bussel Amy, Chua Streamson C

Abstract excerpt

Previous breeding for the diet-induced obese (DIO) trait from outbred Sprague-Dawley rats produced a substrain with selection characteristics suggesting a polygenic mode of inheritance. To assess this issue further, selectively bred DIO male rats were crossed with obesity-resistant inbred Fischer F344 dams. Male offspring were crossed twice more against female F344 dams. The resultant N3 (F.DIO) rats were then...

Topics

Animals
Disease Models, Animal
Energy Intake
Energy Metabolism
Female
Glucose Intolerance
Male
Motor Activity
Obesity
Phenotype
Pregnancy
Rats
Rats, Inbred F344
Rats, Mutant Strains
Rats, Sprague-Dawley

Source

Open in PubMed

Identifiers

PMID: 12855420
DOI: 10.1152/ajpregu.00267.2003

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