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Article

A new obesity-prone, glucose-intolerant rat strain (F.DIO).

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Nov 2003

Levin Barry E, Dunn-Meynell Ambrose A, McMinn Julie E, Alperovich Michael, Cunningham-Bussel Amy, Chua Streamson C

Abstract excerpt

Previous breeding for the diet-induced obese (DIO) trait from outbred Sprague-Dawley rats produced a substrain with selection characteristics suggesting a polygenic mode of inheritance. To assess this issue further, selectively bred DIO male rats were crossed with obesity-resistant inbred Fischer F344 dams. Male offspring were crossed twice more against female F344 dams. The resultant N3 (F.DIO) rats were then...

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PMID: 12855420
DOI: 10.1152/ajpregu.00267.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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