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Article

Selective mutation of codons 204 and 213 of the p53 gene in rat tumors induced by alkylating N-nitroso compounds.

Cancer research - 15 May 1992

Ohgaki H, Hard G C, Hirota N, Maekawa A, Takahashi M, Kleihues P

Abstract excerpt

Kidney and esophageal tumors induced by alkylating N-nitroso compounds in rats contain a high incidence (75-100%) of G----A transition mutations in the p53 gene. These are almost selectively (89%) located in the first base of codon 204 and the second base of 213, leading to amino acid substitutions Glu----Lys and Arg----Gln, respectively. In contrast to human neoplasms, a considerable fraction of rat kidney and...

Topics

Acylation
Alleles
Animals
Base Sequence
Codon
Exons
Genes, p53
Kidney Neoplasms
Molecular Sequence Data
Mutation
Neoplasms, Experimental
Nitroso Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred Strains

Wilms Tumor

Source

Identifiers

PMID: 1316233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1316233-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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