Primary mutations in calmodulin prevent activation of the Ca(++)-dependent Na+ channel in Paramecium.

doi:10.1002/prot.340120408

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Article

Primary mutations in calmodulin prevent activation of the Ca(++)-dependent Na+ channel in Paramecium.

Proteins - 1 Apr 1992

Ling K Y, Preston R R, Burns R, Kink J A, Saimi Y, Kung C

Abstract excerpt

Paramecium tetraurelia behavioral mutant cam12 displays a "fast-2" behavioral phenotype: it fails to respond to Na+ stimuli. Electrophysiologically, it lacks a Ca(++)-dependent Na+ current. Genetics and DNA sequencing showed the primary defect of cam12 to be in the calmodulin gene (Kink et al., 1...

Topics

Amino Acid Sequence
Amino Acids
Animals
Calcium
Calmodulin
Electrophysiology
Molecular Sequence Data
Mutation
Paramecium
Sodium Channels

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