Article
Defect of cold-sensitive response in calmodulin mutants of Paramecium and the restoration by cyclic nucleotide.
Cell structure and function - 1 Oct 1997
Kuriu T, Oosawa Y, Watanabe Y, Nakaoka Y
Abstract excerpt
Wild type and calmodulin mutants (cam) of Paramecium tetraurelia were examined for cold-sensitive responses. Among mutants tested, cam12 and cam13 mutants, which have substitutions in N-terminal lobe of calmodulin molecule, reduced both responses in the swimming and the membrane potential. Under voltage clamp conditions, the cooling stimulus to the wild type cell induced a transient inward current whose amplitude...
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