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Article

New non-lethal calmodulin mutations in Paramecium. A structural and functional bipartition hypothesis.

European journal of biochemistry - 1 Jun 1994

Ling K Y, Maley M E, Preston R R, Saimi Y, Kung C

Abstract excerpt

The mechanisms by which calmodulin coordinates its numerous molecular targets in living cells remain largely unknown. To further understand how this pivotal Ca(2+)-binding protein functions in vivo, we isolated and studied nine new Paramecium behavioral mutants defective in calmodulin. Nucleotide sequences of mutant calmodulin genes indicated single amino-acid substitutions in mutants cam4(E104K), cam5-1 (D95G),...

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PMID: 8020480
DOI: 10.1111/j.1432-1033.1994.tb18882.x

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New non-lethal calmodulin mutations in Paramecium. A structural and functional bipartition hypothesis.PMID 8020480Read ↗

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