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Article

An intragenic suppressor of a calmodulin mutation in Paramecium: genetic and biochemical characterization.

Genetics - 1 Nov 1991

Hinrichsen R D, Pollock M, Hennessey T, Russell C

Abstract excerpt

We describe a suppressor of the calmodulin mutant cam1 in Paramecium tetraurelia. The cam1 mutant, which has a SER----PHE change at residue 101 of the third calcium-binding domain, inhibits the activity of the Ca(2+)-dependent K+ current and causes exaggerated behavioral responses to most stimuli. An enrichment scheme, based on an increased sensitivity to Ba2+ in cam1 cells, was used to isolate suppressors. One...

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Identifiers

PMID: 1661255
DOI: 10.1093/genetics/129.3.717
PMCID: PMC1204739

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An intragenic suppressor of a calmodulin mutation in Paramecium: genetic and biochemical characterization.PMID 1661255Read ↗

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