Article
Mutations in paramecium calmodulin indicate functional differences between the C-terminal and N-terminal lobes in vivo.
Cell - 13 Jul 1990
Kink J A, Maley M E, Preston R R, Ling K Y, Wallen-Friedman M A, Saimi Y, Kung C
Abstract excerpt
We examined calmodulin and its gene from the wild-type and viable mutants of P. tetraurelia. The mutants, selected for their behavioral aberrations, have little or no defects in growth rates, secretion, excretion, or motility. They can be grouped according to whether they underreact or overreact behaviorally to certain stimuli, reflecting their respective loss of either a Ca2(+)-dependent Na+ current or a...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Calmodulin
- Genes
- Molecular Sequence Data
- Mutation
- Paramecium
- Potassium Channels
- Protein Conformation
- Sodium Channels