Functional assay of a putative Drosophila sodium channel gene in homozygous deficiency neurons.

Abstract excerpt

Using voltage-clamp techniques, we have examined embryonic sodium currents in neurons deficient for a gene located at 60E5/6 that shares extensive amino acid similarity with vertebrate sodium channel genes. These neurons expressed sodium currents similar to wildtype, supporting the hypothesis that para, and not the gene at 60E5/6, is the primary sodium channel gene expressed in embryonic neurons. A simple marking...

Topics

• Animals
• Cells, Cultured
• Chromosome Deletion
• Chromosome Mapping
• Drosophila
• Homozygote
• Ion Channel Gating
• Larva
• Mutation
• Neurons
• Phenotype
• Sequence Homology, Nucleic Acid