Drosophila sodium channel mutations: Contributions to seizure-susceptibility.

doi:10.1016/j.expneurol.2015.06.018

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Article

Drosophila sodium channel mutations: Contributions to seizure-susceptibility.

Experimental neurology - 1 Dec 2015

Kroll Jason R, Saras Arunesh, Tanouye Mark A

Abstract excerpt

This paper reviews Drosophila voltage-gated Na(+) channel mutations encoded by the para (paralytic) gene and their contributions to seizure disorders in the fly. Numerous mutations cause seizure-sensitivity, for example, para(bss1), with phenotypes that resemble human intractable epilepsy in some aspects. Seizure phenotypes are also seen with human GEFS+ spectrum mutations that have been knocked into the...

Topics

Animals
Disease Susceptibility
Drosophila
Drosophila Proteins
Humans
Mutation
Seizures
Sodium Channels

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Identifiers

PMID: 26093037
DOI: 10.1016/j.expneurol.2015.06.018
PMCID: PMC4644469

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