napts, a mutation affecting sodium channel activity in Drosophila, is an allele of mle, a regulator of X chromosome transcription.

Abstract excerpt

napts is a recessive mutation that affects the level of sodium channel activity and, at high temperature, causes paralysis associated with a loss of action potentials. We show, by genetic complementation tests, germline transformation, and analysis of mutations, that napts is a gain-of-function mutation of mle, a gene required for X chromosome dosage compensation and male viability. Molecular analyses of nap and...

Topics

• Action Potentials
• Alleles
• Animals
• Dosage Compensation, Genetic
• Drosophila melanogaster
• Gene Expression Regulation
• Genes, Regulator
• Genetic Complementation Test
• Mutation
• Paralysis
• Sodium Channels