Article
Screening for synaptic defects revealed a locus involved in presynaptic and postsynaptic functions in Drosophila embryos.
Journal of neurobiology - 1 Aug 2001
Takasu-Ishikawa E, Yoshihara M, Ueda A, Rheuben M B, Hotta Y, Kidokoro Y
Abstract excerpt
To identify genes involved in synaptic functions, we screened lethal enhancer trap lines by monitoring synaptic activities at the neuromuscular junction in Drosophila embryos. It was found that MY7919, thus isolated, has moderate defects in both pre- and postsynaptic functions. The mean amplitudes of spontaneous as well as evoked synaptic currents were smaller than those in wild-type. The failure rate was higher...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Calcium
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Electrophysiology
- Enhancer Elements, Genetic
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Genetic Testing
- Homozygote