Article
Examination of paralysis in Drosophila temperature-sensitive paralytic mutations affecting sodium channels; a proposed mechanism of paralysis.
Journal of neurobiology - 1 Apr 1990
Nelson J C, Wyman R J
Abstract excerpt
We have used the identified cells of the Drosophila Giant Fiber System (GFS) to study the defects induced by the temperature-sensitive paralytic mutations no action potential (nap) and paralytic (para). These mutations paralyze at elevated temperatures, reported as due to a block of action potential propagation. We found, however, that the cells of the GFS still were able to respond to stimuli at 7-10 degrees C...
Topics
- Action Potentials
- Animals
- Central Nervous System
- Drosophila
- Electric Stimulation
- Motor Neurons
- Mutation
- Neural Conduction
- Paralysis
- Sodium Channels
- Temperature