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Article

NF-kappa B inhibits glucocorticoid and cAMP-mediated expression of the phosphoenolpyruvate carboxykinase gene.

The Journal of biological chemistry - 13 Oct 2000

Waltner-Law M, Daniels M C, Sutherland C, Granner D K

Abstract excerpt

Transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene is regulated by a variety of agents. Glucocorticoids, retinoic acid, and glucagon (via its second messenger, cAMP) stimulate PEPCK gene transcription, whereas insulin, phorbol esters, cytokines, and oxidative stress have an opposing effect. Stimulation of PEPCK gene expression has been extensively studied, and a number of important DNA elements...

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PMID: 10913132
DOI: 10.1074/jbc.M003656200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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NF-kappa B inhibits glucocorticoid and cAMP-mediated expression of the phosphoenolpyruvate carboxykinase gene.PMID 10913132Read ↗

Identification of a Sequence in the PEPCK Gene That Mediates a Negative Effect of Insulin on TranscriptionSemantic proximity Read ↗

Response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids depends on the integrity of the cAMP pathway.Semantic proximity Read ↗

The role of the TATA box in the hormonal regulation of phosphoenolpyruvate carboxykinase gene expression.Semantic proximity Read ↗

Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements.Semantic proximity Read ↗

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Glucocorticoid Repression of AP-1 Is Not Mediated by Competition for Nuclear CoactivatorsSemantic proximity Read ↗

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The Glucose-6-Phosphatase Catalytic Subunit Gene Promoter Contains Both Positive and Negative Glucocorticoid Response ElementsSemantic proximity Read ↗

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