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Article

Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.

Molecular and cellular biology - 1 Feb 1992

Dieken E S, Miesfeld R L

Abstract excerpt

Genetic studies have suggested that transcriptional regulation of specific target genes (by either induction or repression) is the molecular basis of glucocorticoid-mediated lymphocyte apoptosis. To examine the role of transcriptional regulation more directly, we developed a complementation assay utilizing stable transfection of wild-type (wt) and mutant (nti) glucocorticoid receptor (GR) cDNA constructs into a...

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Identifiers

PMID: 1310148
DOI: 10.1128/mcb.12.2.589-597.1992
PMCID: PMC364237

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