Article
Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.
Molecular and cellular biology - 1 Feb 1992
Dieken E S, Miesfeld R L
Abstract excerpt
Genetic studies have suggested that transcriptional regulation of specific target genes (by either induction or repression) is the molecular basis of glucocorticoid-mediated lymphocyte apoptosis. To examine the role of transcriptional regulation more directly, we developed a complementation assay...
Topics
- Animals
- Cell Death
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Colony-Forming Units Assay
- Dexamethasone
- Gene Expression Regulation
- Genetic Complementation Test
- Lymphocytes
- Mutation
- Plasmids
- Receptors, Glucocorticoid
- Recombinant Fusion Proteins
- Simplexvirus
- Transcription, Genetic
- Transcriptional Activation
- Transfection
- Viral Proteins