A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors.

doi:10.1210/endo.135.5.7956941

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Article

A conserved carboxy-terminal subdomain is important for ligand interpretation and transactivation by nuclear receptors.

Endocrinology - 1 Nov 1994

Lanz R B, Rusconi S

Abstract excerpt

Nuclear receptors share a highly conserved region located at the very carboxy-terminal part of the ligand-binding domain. Site-directed mutagenesis of conserved hydrophobic residues in this region was reported to create mouse and human glucocorticoid receptors (GRs) and estrogen receptors that ca...

Topics

Alanine
Amino Acid Sequence
Animals
Cell Line
Dexamethasone
Ligands
Mifepristone
Molecular Sequence Data
Mutation
Receptors, Androgen
Receptors, Glucocorticoid
Receptors, Mineralocorticoid
Receptors, Progesterone
Transcriptional Activation
Transfection

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