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Article

Identification of target genes involved in the antiproliferative effect of glucocorticoids reveals a role for nuclear factor-(kappa)B repression.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2005

Bladh Lars-Göran, Lidén Johan, Pazirandeh Ahmad, Rafter Ingalill, Dahlman-Wright Karin, Nilsson Stefan, Okret Sam

Abstract excerpt

Glucocorticoid hormones (GCs) exert an antiproliferative effect on most cells. However, the molecular mechanism is still largely unclear. We investigated the antiproliferative mechanism by GCs in human embryonic kidney 293 cells with stably introduced glucocorticoid receptor (GR) mutants that discriminate between cross-talk with nuclear factor-(kappa)B (NF-(kappa)B) and activator protein-1 signaling,...

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PMID: 15528271
DOI: 10.1210/me.2004-0294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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