Article
Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.
Pharmacogenetics - 1 Oct 1992
Hickman D, Risch A, Camilleri J P, Sim E
Abstract excerpt
Arylamine N-acetyltransferase catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. N-acetylation is subject to a polymorphism and humans can be categorized as either fast or slow acetylators according to their ability to N-acetylate polymorphic substrates in vivo. Previously, slow acetylation has been linked to four distinct polymorphic N-acetyltransferase (pnat) alleles each of...
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