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Article

Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.

Pharmacogenetics - 1 Oct 1992

Hickman D, Risch A, Camilleri J P, Sim E

Abstract excerpt

Arylamine N-acetyltransferase catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. N-acetylation is subject to a polymorphism and humans can be categorized as either fast or slow acetylators according to their ability to N-acetylate polymorphic substrates in vivo. Previously, slow acetylation has been linked to four distinct polymorphic N-acetyltransferase (pnat) alleles each of...

Topics

Adult
Aged
Alleles
Arylamine N-Acetyltransferase
Base Sequence
Cloning, Molecular
DNA
Gene Amplification
Genotype
Humans
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Penicillamine

Polymerase Chain Reaction

Polymorphism, Genetic

Proteinuria

Source

Identifiers

PMID: 1306121
DOI: 10.1097/00008571-199210000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1306121-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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