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Article

Cytogenetic and FMS-like tyrosine kinase 3 mutation analyses in acute promyelocytic leukemia patients.

Iranian biomedical journal - 1 Jan 2012

Yaghmaie Marjan, Alimoghaddam Kamran, Mozdarani Hossein, Ghavamzadeh Ardeshir, Hajhashemi Marjan, Aznab Mozaffar, Ghaffari Seyed H

Abstract excerpt

BACKGROUND: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutations in acute...

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Source

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Identifiers

PMID: 22562027
DOI: 10.6091/ibj.961.2012
PMCID: PMC3614257

Genes

FLT3
PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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