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Article

Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18.

Genetics - 6 Dec 2023

Boeglin Marion, Leyva-Díaz Eduardo, Hobert Oliver

Abstract excerpt

Sec1/Munc18 (SM) proteins are important regulators of SNARE complex assembly during exocytosis throughout all major animal tissue types. However, expression of a founding member of the SM family, UNC-18, is mostly restricted to the nervous system of the nematode Caenorhabditis elegans, where it is important for synaptic transmission. Moreover, unc-18 null mutants do not display the lethality phenotype associated...

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Identifiers

PMID: 37793339
DOI: 10.1093/genetics/iyad180
PMCID: PMC10697816

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