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Distal control of mitochondrial biogenesis and respiratory activity by extracellular lactate caused by large-scale deletion of mitochondrial DNA.

Pharmacological research - 1 Oct 2020

Ogasawara Emi, Nakada Kazuto, Ishihara Naotada

Abstract excerpt

Lactate is highly produced under conditions of respiratory dysfunction such as anaerobic respiration and various types of mitochondrial diseases, and it was also known as an active molecule that plays various roles both within and between cells. High levels of extracellular lactate may lead to lactic acidosis, which has been related to pathology of the mitochondrial diseases with mutated mitochondrial DNA...

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PMID: 32946932
DOI: 10.1016/j.phrs.2020.105204

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