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Article

BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas.

Cancer letters - 8 May 2007

Schönleben Frank, Qiu Wanglong, Bruckman Karl C, Ciau Nancy T, Li Xiaojun, Lauerman Margaret H, Frucht Harold, Chabot John A, Allendorf John D, Remotti Helen E, Su Gloria H

Abstract excerpt

The Raf/MEK/ERK (MAPK) signal transduction is an important mediator of a number of cellular fates including growth, proliferation, and survival. The BRAF gene is activated by oncogenic RAS, leading to cooperative effects in cells responding to growth factor signals. Our study was performed to elucidate a possible role of BRAF in the development of IPMN (Intraductal Papillary Mucinous Neoplasm) and IPMC...

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Share to Adenocarcinoma, Mucinous
Share to Adenocarcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Carcinoma, Pancreatic Ductal

Share to Genes, ras

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 17097223
DOI: 10.1016/j.canlet.2006.09.007
PMCID: PMC1865507

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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