Article
Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS2 mutations.
Digestion - 1 Jan 2008
Felderbauer Peter, Stricker Ingo, Schnekenburger Jurgen, Bulut Kerem, Chromik Ansgar M, Belyaev Orlin, Muller Christophe A, Uhl Waldemar, Tannapfel Andrea, Schmidt Wolfgang E
Abstract excerpt
BACKGROUND/AIMS: Hereditary pancreatitis (HP) is a rare cause of chronic pancreatitis (CP; 1%) and more than 25 mutations in the PRSS1 gene have been detected. HP patients with the p.R122H mutation have a 35% lifetime risk of developing pancreatic cancer, but the oncogenetic process remains unkno...
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