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Article

Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation.

International journal of molecular medicine - 1 Oct 2003

Fukuoka Masahiro, Daitoku Hiroaki, Hatta Mitsutoki, Matsuzaki Hitomi, Umemura Satoshi, Fukamizu Akiyoshi

Abstract excerpt

AFX (also called Foxo4), a member of mammalian FOXO forkhead transcription factors, is the homolog of DAF-16, which contributes longevity and oxidative stress in Caenorhabditis elegans. Here, we show that CREB-binding protein (CBP) interacts with AFX via CH1 region and acetylates it at the three lysine residues (K186, K189, and K408). Trichostatin A (TSA) repressed the AFX-stimulated transcription, and...

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PMID: 12964026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation.PMID 12964026Read ↗

Dynamic FoxO transcription factorsSemantic proximity Read ↗

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.Semantic proximity Read ↗

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