Article
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2005
Matsuzaki Hitomi, Daitoku Hiroaki, Hatta Mitsutoki, Aoyama Hisanori, Yoshimochi Kenji, Fukamizu Akiyoshi
Abstract excerpt
The FOXO family of forkhead transcription factors plays a key role in a variety of biological processes, including metabolism, cell proliferation, and oxidative stress response. We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by histone acetyltransferase cAMP-response element-binding protein (CREB)-binding protein (CBP) and NAD-dependent...
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