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Article

The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex.

The Journal of biological chemistry - 26 Jul 2013

van den Berg Maaike C W, van Gogh Inkie J A, Smits Alida M M, van Triest Miranda, Dansen Tobias B, Visscher Marieke, Polderman Paulien E, Vliem Marjolein J, Rehmann Holger, Burgering Boudewijn M T

Abstract excerpt

FOXO (forkhead box O) transcription factors are tumor suppressors and increase the life spans of model organisms. Cellular stress, in particular oxidative stress caused by an increase in levels of reactive oxygen species (ROS), activates FOXOs through JNK-mediated phosphorylation. Importantly, JN...

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Source

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Identifiers

PMID: 23770673
DOI: 10.1074/jbc.M113.463885
PMCID: PMC3724631

Genes

RALA
RLF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23770673-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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