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Article

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.

Nature - 13 Apr 2000

Medema R H, Kops G J, Bos J L, Burgering B M

Abstract excerpt

The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a Forkhead factor that regulates longevity in Caenorhabditis elegans. Here we show that overexpression of these Forkhead transcription factors causes growth suppression in a variety of cell lines, including a Ras-transformed cell line and a cell line lacking the tumour suppressor PTEN. Expression of AFX blocks cell-cycle...

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Source

Identifiers

PMID: 10783894
DOI: 10.1038/35008115

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.PMID 10783894Read ↗

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