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Article

Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.

The Journal of experimental medicine - 15 Sept 2003

Amyes Elisabeth, Hatton Chris, Montamat-Sicotte Damien, Gudgeon Nancy, Rickinson Alan B, McMichael Andrew J, Callan Margaret F C

Abstract excerpt

The CD8+ T cell response to Epstein-Barr virus (EBV) is well characterized. Much less is known about the evolution of the CD4+ T cell response. Here we show that EBV stimulates a primary burst of effector CD4+ T cells and this is followed by a period of down-regulation. A small population of EBV-specific effector CD4+ T cells survives during the lifelong persistent phase of infection. The EBV-specific effector...

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Identifiers

PMID: 12975456
DOI: 10.1084/jem.20022058
PMCID: PMC2194204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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