Article
Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells.
Virology - 15 Mar 2010
Tovar-Salazar Adriana, Patterson-Bartlett Julie, Jesser Renee, Weinberg Adriana
Abstract excerpt
CMV infection is characterized by high of frequencies of CD27-CD28- T cells. Here we demonstrate that CMV-specific CD4+CD27-CD28- cells are regulatory T cells (TR). CD4+CD27-CD28- cells sorted from CMV-stimulated PBMC of CMV-seropositive donors inhibited de novo CMV-specific proliferation of autologous PBMC in a dose-dependent fashion. Compared with the entire CMV-stimulated CD4+ T-cell population, higher...
Topics
- Antigens, CD
- Apoptosis Regulatory Proteins
- CD28 Antigens
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Cell Line
- Cytomegalovirus
- Cytomegalovirus Infections
- Epitopes
- Forkhead Transcription Factors
- Granzymes
- HIV Infections
- Humans
- Lymphocyte Activation