Article
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections.
Nature medicine - 1 Apr 2002
Appay Victor, Dunbar P Rod, Callan Margaret, Klenerman Paul, Gillespie Geraldine M A, Papagno Laura, Ogg Graham S, King Abigail, Lechner Franziska, Spina Celsa A, Little Susan, Havlir Diane V, Richman Douglas D, Gruener Norbert, Pape Gerd, Waters Anele, Easterbrook Philippa, Salio Mariolina, Cerundolo Vincenzo, McMichael Andrew J, Rowland-Jones Sarah L
Abstract excerpt
The viruses HIV-1, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and hepatitis C virus (HCV) are characterized by the establishment of lifelong infection in the human host, where their replication is thought to be tightly controlled by virus-specific CD8+ T cells. Here we present detailed studies of the differentiation phenotype of these cells, which can be separated into three distinct subsets based on...
Topics
- Adolescent
- Adult
- Aged
- CD28 Antigens
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Child
- Child, Preschool
- Cytomegalovirus Infections