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Article

Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers.

PloS one - 18 Mar 2011

Madsen Karina M, Udatha Gupta D B R K, Semba Saori, Otero Jose M, Koetter Peter, Nielsen Jens, Ebizuka Yutaka, Kushiro Tetsuo, Panagiotou Gianni

Abstract excerpt

BACKGROUND: Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective. A systematic experimental or computational survey of all feasible gene modifications to determine the genotype yielding the optimal triterpene production phenotype is a...

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Identifiers

PMID: 21445244
DOI: 10.1371/journal.pone.0014763
PMCID: PMC3060802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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