Article
Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2003
Clancy Robert M, Backer Chelsea B, Yin Xiaoming, Kapur Raj P, Molad Yair, Buyon Jill P
Abstract excerpt
Although Abs to SSA/Ro-SSB/La are necessary for the development of congenital heart block (CHB), the low frequency suggests that fetal factors are contributory. Because CHB involves a cascade from inflammation to scarring, polymorphisms of the TNF-alpha promoter region and codons 10 and 25 of the...
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