Article
Genetic variability in tumor necrosis factor production: relevance to predisposition to autoimmune disease.
Regional immunology - 1 Jan 2000
Jacob C O
Abstract excerpt
Rather than being involved merely in the effector arm of inflammatory processes that contribute to autoimmune organ destruction, a primary involvement of TNF may be in some of the more basic mechanisms that occur in autoimmune disease. In this review, data are presented on TNF-alpha that suggest the involvement of this cytokine in the genetic predisposition to autoimmune diseases such as lupus nephritis.
Topics
- Animals
- Autoimmune Diseases
- Diabetes Mellitus, Experimental
- Gene Expression Regulation
- Genes, MHC Class II
- Genetic Variation
- Humans
- Lupus Erythematosus, Systemic
- Malaria
- Mice
- Tumor Necrosis Factor-alpha