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Siglec-1 Macrophages and the Contribution of IFN to the Development of Autoimmune Congenital Heart Block

5 Dec 2018

Abstract excerpt

Abstract Given that diseases associated with anti-SSA/Ro autoantibodies, such as systemic lupus erythematosus and Sjögren syndrome, are linked with an upregulation of IFN and type I IFN–stimulated genes, including sialic acid–binding Ig-like lectin 1 (Siglec-1), a receptor on monocytes/macrophages, recent attention has focused on a potential role for IFN and IFN-stimulated genes in the pathogenesis of congenital...

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PMID: 30518570
DOI: 10.4049/jimmunol.1800357

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