Article
Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease.
Biological psychiatry - 1 Mar 2004
Lewczuk Piotr, Esselmann Hermann, Groemer Teja Wolfgang, Bibl Mirko, Maler Juan Manuel, Steinacker Petra, Otto Markus, Kornhuber Johannes, Wiltfang Jens
Abstract excerpt
BACKGROUND: The advent of new therapeutic avenues for Alzheimer's disease (AD) calls for an improved early and differential diagnosis. METHODS: With surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), cerebrospinal fluid from patients with AD (n = 10) and nondemented control subjects (n = 9) was studied. RESULTS: Molecular mass signals were observed corresponding to three...
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