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Article

Decreased alpha-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's disease.

Nature medicine - 1 Aug 1995

Lannfelt L, Basun H, Wahlund L O, Rowe B A, Wagner S L

Abstract excerpt

The neuropathologic hallmarks of Alzheimer's disease (AD) are extracellular plaques and intracellular neurofibrillary tangles. A constituent of senile plaques in AD is beta-amyloid, a hydrophobic peptide of 39-43 amino acids and a fragment of the amyloid precursor protein (APP). APP can be metabolized by at least two pathways, one of which involves generation of soluble APP by an unidentified enzyme named...

Topics

Adult
Aged
Alzheimer Disease
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Aspartic Acid Endopeptidases
Biomarkers
Blotting, Western
Endopeptidases
Enzyme-Linked Immunosorbent Assay
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Mutation

Peptide Fragments

Sweden

Source

Identifiers

PMID: 7585189
DOI: 10.1038/nm0895-829

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7585189-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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