Article
The calculated genetic barrier for antiretroviral drug resistance substitutions is largely similar for different HIV-1 subtypes.
Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2006
van de Vijver David A, Wensing Annemarie M J, Angarano Gioacchino, Asjö Birgitta, Balotta Claudia, Boeri Enzo, Camacho Ricardo, Chaix Marie-Laure, Costagliola Dominique, De Luca Andrea, Derdelinckx Inge, Grossman Zehava, Hamouda Osamah, Hatzakis Angelos, Hemmer Robert, Hoepelman Andy, Horban Andrzej, Korn Klaus, Kücherer Claudia, Leitner Thomas, Loveday Clive, MacRae Eilidh, Maljkovic Irina, de Mendoza Carmen, Meyer Laurence, Nielsen Claus, Op de Coul Eline L M, Ormaasen Vidar, Paraskevis Dimitris, Perrin Luc, Puchhammer-Stöckl Elisabeth, Ruiz Lidia, Salminen Mika, Schmit Jean-Claude, Schneider Francois, Schuurman Rob, Soriano Vincent, Stanczak Grzegorz, Stanojevic Maja, Vandamme Anne-Mieke, Van Laethem Kristel, Violin Michela, Wilbe Karin, Yerly Sabine, Zazzi Maurizio, Boucher Charles A B
Abstract excerpt
BACKGROUND: The genetic barrier, defined as the number of mutations required to overcome drug-selective pressure, is an important factor for the development of HIV drug resistance. Because of high variability between subtypes, particular HIV-1 subtypes could have different genetic barriers for drug resistance substitutions. This study compared the genetic barrier between subtypes using some 2000 HIV-1 sequences...
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