Article
VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling.
Molecular and cellular biology - 1 Feb 2001
Davidowitz E J, Schoenfeld A R, Burk R D
Abstract excerpt
Mutations in the von Hippel-Lindau (VHL) gene are involved in the family cancer syndrome for which it is named and the development of sporadic renal cell cancer (RCC). Reintroduction of VHL into RCC cells lacking functional VHL [VHL(-)] can suppress their growth in nude mice, but not under standard tissue culture conditions. To examine the hypothesis that the tumor suppressor function of VHL requires signaling...
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