Article
Human neoplastic submandibular intercalated duct cells express an acinar phenotype when cultured on a basement membrane matrix.
Differentiation; research in biological diversity - 1 Mar 1993
Royce L S, Kibbey M C, Mertz P, Kleinman H K, Baum B J
Abstract excerpt
Culture of the human neoplastic submandibular gland intercalated duct cell line, HSG, on the basement membrane extract Matrigel induces dramatic morphologic changes and cytodifferentiation. Transmission electron microscopy demonstrated an acinar cell phenotype with polarized cells containing a well-developed Golgi apparatus, multiple microvilli-like projections from the apical surfaces into a lumenal-like area,...
Topics
- Amylases
- Animals
- Cell Differentiation
- Collagen
- Drug Combinations
- Humans
- Laminin
- Phenotype
- Proteoglycans
- Rabbits
- Submandibular Gland Neoplasms