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Article

Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T.

The Journal of clinical investigation - 1 Sept 2003

Javadpour Maryam M, Tardiff Jil C, Pinz Ilka, Ingwall Joanne S

Abstract excerpt

The thin filament protein cardiac troponin T (cTnT) is an important regulator of myofilament activation. Here we report a significant change in cardiac energetics in transgenic mice bearing the missense mutation R92Q within the tropomyosin-binding domain of cTnT, a mutation associated with a clin...

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Identifiers

PMID: 12952925
DOI: 10.1172/JCI15967
PMCID: PMC182182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12952925-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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