Article
Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2005
Ertz-Berger Briar R, He Huamei, Dowell Candice, Factor Stephen M, Haim Todd E, Nunez Sara, Schwartz Steven D, Ingwall Joanne S, Tardiff Jil C
Abstract excerpt
Cardiac troponin T (cTnT) is a central component of the regulatory thin filament. Mutations in cTnT have been linked to severe forms of familial hypertrophic cardiomyopathy. A mutational "hotspot" that leads to distinct clinical phenotypes has been identified at codon 92. Although the basic functional and structural roles of cTnT in modulating contractility are relatively well understood, the mechanisms that link...
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