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Article

Temporal and mutation-specific alterations in Ca<sup>2+</sup> homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models

5 Jun 2009

Abstract excerpt

Naturally occurring mutations in cardiac troponin T (cTnT) result in a clinical subset of familial hypertrophic cardiomyopathy. To determine the mechanistic links between thin-filament mutations and cardiovascular phenotypes, we have generated and characterized several transgenic mouse models carrying cTnT mutations. We address two central questions regarding the previously observed changes in myocellular...

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PMID: 19502551
DOI: 10.1152/ajpheart.01143.2008

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