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Article

Functional consequence of mutation in rat cardiac troponin T is affected differently by myosin heavy chain isoforms.

The Journal of physiology - 1 Jul 2006

Tschirgi Matthew L, Rajapakse Indika, Chandra Murali

Abstract excerpt

Cardiac troponin T (cTnT) is an essential component of the thin filament regulatory unit (RU) that regulates Ca2+ activation of tension in the heart muscle. Because there is coupling between the RU and myosin crossbridges, the functional outcome of cardiomyopathy-related mutations in cTnT may be modified by the type of myosin heavy chain (MHC) isoform. Ca2+ activation of tension and ATPase activity were measured...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16644804
DOI: 10.1113/jphysiol.2006.107417
PMCID: PMC1817786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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