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Article

Roles for E-cadherin cell surface regulation in cancer

31 Aug 2016

Abstract excerpt

The loss of E-cadherin expression in association with the epithelial-mesenchymal transition (EMT) occurs frequently during tumor metastasis. However, metastases often retain E-cadherin expression, an EMT is not required for metastasis, and metastases can arise from clusters of tumor cells. We demonstrate that the regulation of the adhesive activity of E-cadherin present at the cell surface by an inside-out...

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PMID: 27582386
DOI: 10.1091/mbc.e16-01-0058

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